Hollow Porous Carbon Coated FeS2-Based Nanocatalysts for Multimodal Imaging-Guided Photothermal, Starvation and Triple-Enhanced Chemodynamic Therapy of Cancer

ABSTRACT: Specific chemical reactions only happen in tumor region and produce abundant special chemicals to in situ trigger a train of biological and pathologic effects that may enable tumor-specific curative effect to treat cancer without causing serious side effects on normal cells or organs. Chemodynamic therapy (CDT) is a rising tactics for cancer therapy, which induces cancer cell death via a localized Fenton reaction. However, tumor therapeutic effect is limited by the efficiency of chemical reaction and relies heavily on catalyst. Here, we constructed hollow porous carbon coated FeS2 (HPFeS2@C)-based nanocatalysts for triple-enhanced CDT. Tannic acid (TA) was encapsulated in HPFeS2@C for reducing Fe3+ to Fe2+ which had a better catalytic activity to accelerate the Fenton reaction. Afterwards, glucose oxidase (GOx) in nanocatalysts could consume glucose in tumor microenvironment (TME), and in situ synchronously produce H2O2 which could improve Fenton reaction efficiency. Meanwhile, the consumption o...