The davantages of transrectal ultrasound-guided 12 + X-core biopsy in the diagnosis of prostate cancer

Objective To summarize the experience in transrectal ultrasound-guided 12+ X-core biopsy and analyze the influencing factors of the biopsy results. Methods Totally, 622 consecutive patients who had a transrectal ultrasonography (TRUS)-guided 12+ X-core biopsy were retrospectively analyzed in the study from Jan. 2010 to Mar. 2016 .The age ranged from 46 to 88 years[mean(68.1±6.8)years], age≤60y (116), age 61-70y (251), age 71-80y (230), age>80y (25). Prostate specific antigen (PSA) ranged from 0.35 to 264ng/ml[mean (28.15±31.42)ng/ml], PSA<4ng/ml(26), 4-9ng/ml(182), 10-19ng/ml(194), 20-39ng/ml(93), 40-59ng/ml( 34), 60-79ng/ml(32), 80-99ng/ml(66), ≥100 ng/ml(5). Every core positive rate, lateral zone and contralateral zone positive rate were analyzed. The biopsy positive rates were also analyzed, adjusted to the age and PSA. The complications were analyzed. The Logistic regression analysis were used for data analysis a. Results Among the 622 patients who underwent 12+ X core prostate biopsy, the pathological result included BPH(314), PIN(31), doubtful-PCa(26) and PCa(231). The positive biopsy rate was 37.1%(231/622). The contralateral zone and lateral zone positive rate was 21.6%(807/3 735)and 21.3%(796/3 736)(P>0.05), respectively. The positive rate of 1-12 core was (21.6±1.6)%(P>0.05)and the positive rate of X core was 34.8%(P 80y (64.0%)(P 38℃), and the complication rate were 13.7%, 5.2%, 4.2%, 9.2%, respectively. Conclusions The age and serum PSA were both related to the positive rate of prostate biopsy and could be used as a prediction to guide the prostate biopsy. The combination of sextant and lateral peripheral zone biopsies (12+ X biopsy scheme) could have an advantage over 6 systematic biopsy and saturate biopsy scheme. Key words: Transrectal ultrasound; Prostate biopsy; Prostate cancer