Real-time suppression and amplification of frequency-specific neural activity using stimulation evoked oscillations

2020 
Background: Approaches to predictably control neural oscillations are needed to understand their causal role in brain function in healthy and diseased states and to advance the development of neuromodulation therapies. In this study, we present a closed-loop neural control and optimization framework to actively suppress or amplify low-frequency neural oscillations observed in local field potentials in real-time by using electrical stimulation. Objective/Hypothesis: The rationale behind this control approach and our working hypothesis is that neural oscillatory activity evoked by electrical pulses can suppress or amplify spontaneous oscillations via destructive or constructive interference when stimulation pulses are continuously delivered with appropriate amplitudes and at precise phases of these oscillations in a closed-loop scheme. Methods: We tested our hypothesis in two nonhuman primates that exhibited a robust increase in low-frequency (8-30 Hz) oscillatory power in the subthalamic nucleus (STN) following administration of the neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). To test our neural control approach, we used electrode arrays and electrical stimulation waveforms similar to those used in humans chronically implanted with brain stimulation systems. Stimulation parameters that maximize the suppression or amplification of neural oscillations were predicted using mathematical models of the stimulation evoked oscillations. Results: Our neural control and optimization approach was capable of actively and robustly suppressing or amplifying oscillations in the targeted frequency band in real-time in the studied subjects. Conclusions: The results from this study support our hypothesis and suggest that the proposed neural control framework allows one to characterize in controlled experiments the functional role of circuit-level neural oscillations by using electrodes and stimulation waveforms currently being used in humans.
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