Effect of mud therapy on the links in the pathogenesis of rheumatoid arthritis in children and adolescents

: One hundred and ninety-nine children aged 7-14 and 177 adolescents in remission and minimal manifestations of rheumatoid arthritis (RA) were examined before and after fangotherapy with allowance for activity of the process, age-related reactivity. The comparison involved sympathetic-adrenal function (by urine excretion of epinephrine and norepinephrine), specific and nonspecific immune reactivity (by the level of IgA, IgM, IgG, circulating immune complexes, T and B lymphocytes; RF titers, leukocyte migration inhibition test), platelet components of hemostasis (number of platelets, adhesion induced by ADP and epinephrine).