Cytogenetic effects of quinoxaline-1,4-dioxide-type growth-promoting agents III. Transplacental micronucleus test in mice

Abstract The growth-promoting agents carbadox and olaquindox were active in the mouse transplacental micronucleus test, whereas cyadox was ineffective. Chemical were administered p.o. and i.p. at a dose of 100 mg/kg and the effect was observed 18 h after treatment. The effects observed in fetal liver were parallel to those in maternal bone marrow, but fetal tissue was approximately 2–3 times more sensitive.