Amithiozone (Tibione) Analogs From Aralkyl Ketones

The antitubercular thiosemicarbazones listed in the literature have been restricted almost exclusively to those derived from aldehydes. In the present report, a group of 18 thiosemicarbazones prepared from aralkyl ketones has been described. The carboxyl or amino group has been introduced into three of the products in an attempt to change their properties or activity. p-Chloroacetophenone thiosemicarbazone was found to have four times the in vitro effectiveness of 4,4′-diaminodiphenyl sulfone.