Potential Role of Calbindins in Enamel Calcification

Cellular elements residing between the source of calcium (blood) and the most highly mineralized substance in the body (enamel) regulate the flow of that divalent cation into the enamel matrix. Enamel formation is a complex two stage process involving secretion and maturation. In this presentation the cellular, subcellular and molecular parameters leading to enamel mineralization are reviewed and a model is presented which proposes a role for calbindin-D9K and calbindin-D28K in that process.