Dalbavancin dosage adjustments not required for patients with mild to moderate renal impairment

Dalbavancin (DAL) is a novel semisynthetic glycopeptide in phase 3 clinical development that has activity against Gram(+) organisms, including resistant strains. Two doses given 1 week apart have been shown to be effective in complicated skin and soft tissue infections. A clinical study was performed to determine the need for dosage adjustments in subjects with mild to moderate renal impairment (RI).