Comparison of glucoheptonate single photon emission computed tomography and contrast-enhanced MRI in detection of recurrent glioma.

Results On the basis of the gold standard, 56 patients were positive and 29 were negative for tumour recurrence. The sensitivity, specificity and accuracy of GHA SPECT were 86.5, 96.5 and 89.4% respectively, whereas those of MRI were 94.6, 24.1 and 70.5% respectively. On subgroup analysis GHA SPECT had similar sensitivities with a much higher specificity than MRI across all grades. Thirty patients had intermodality discordance, with GHA SPECT being correct in 23 of them.