Investigation Into the Comparative Efficacy of Three West Nile Virus Vaccines in Experimentally Induced West Nile Virus Clinical Disease in Horses

This is the first report of a comparative vaccine-efficacy trial in horses where West Nile Virus-induced encephalomyelitis was shown in all of the control animals. These studies show differences in the abilities of two commercial vaccines and a live-chimera vaccine to protect against West Nile Virus-induced disease at 28 days post-vaccination in horses. Authors’ addresses: Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608 (Seino, Long, Beachboard, Humphrey, Dixon); and Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608 (Gibbs); e-mail: seinok@mail.vetmed.ufl.edu (Seino). © 2006 AAEP.