RE-13 : Efficacy of hyaluronan-rich transfer medium in fresh and frozen-thawed blastocyst transfer in patients with previous implantation failure

목적: To evaluate the efficacy of hyaluronan-rich transfer medium in fresh and frozen-thawed blastocyst transfer in patients with a history of previous implantation failures. 방법: The study included 283 blastocyst transfers in patients with previous implantation failure. Blastocyst transfers were performed using hyaluronan- rich transfer medium in study group, and conventional transfer medium was used in the control group. According to the type of transfer (fresh elective [n=123] or frozen-thawed [n=160]), all participants were divided into two study and two control groups. 결과: The patient`s mean age (35.68 ± 0.42 versus 36.11 ± 0.28), serum anti-Mullerian hormone level (4.51 ± 0.58 ng/ml versus 4.54 ± 0.38 ng/ml), and the number of transferred embryos (1.89 ± 0.04 versus 1.91 ± 0.02) were comparable between study and control group. There were no significant differences in clinical pregnancy rate (45.5% versus 43.1%) and implantation rate (28.98 ± 3.78% versus 29.32 ± 2.73%) between two groups. In subgroup analysis, no statistically significant differences were found in clinical pregnancy rate after fresh elective transfers (46.9% versus 38.5%) or frozen-thawed transfers (44.6% versus 47.1%). 결론: The use of hyaluronan-rich transfer medium does not appear to have any significant effect on pregnancy rates in patients with previous implantation failure.