Spatiotemporal clutter filtering methods for in vivo microvessel imaging

Ultrafast plane wave imaging enables acquisition and accumulation of a large number of Doppler ensembles in a short period of time, which substantially boosts ultrasound Doppler sensitivity by at least an order of magnitude. As a key component, spatiotemporal clutter filtering based on singular value decomposition (SVD) has recently demonstrated superior performance in tissue clutter suppression and microvessel signal extraction over conventional high-pass-filter-based clutter filtering techniques. This presentation introduces several novel SVD clutter filter techniques from our recent work, focusing on addressing the technical challenges (complex tissue motion, high computational cost, and noise) of SVD clutter filter during clinical translations of the ultrafast microvessel imaging technology for human imaging. We present a block-wise adaptive SVD filter method that can robustly threshold singular values on a local level, a real-time feasible SVD clutter filtering method based on partial SVD and randomi...