IL33 rs1342326 polymorphism, though associated with severe post-bronchiolitis asthma, showed no association with lung function.

Interleukin-33 (IL-33), a cytokine of the IL-1 family, has both pro-inflammatory and anti-inflammatory properties and shares a common receptor with IL-1. Single nucleotide polymorphism (SNP) at rs1342326 of the IL33 gene was associated with allergic rhinitis in preschool-aged children from five European countries (1), and has been associated with wheezing, asthma and hospitalisation for asthma in other child populations (2).