Hydrogen-bonding reinforced injectable hydrogels: Application as a thermo-triggered drug controlled-release system
2020
Most injectable hydrogels
are prone to irreversible deformation
or damage under sustained shear forces and exhibit low mechanical
properties, which limit their practical applications in biological
engineering. In this work, the first hydrogen-bonding reinforced injectable
thermoresponsive hydrogel system has been fabricated through an in
situ hydrazide–aldehyde cross-linking reaction between hydrazide-functionalized
poly(N-isopropylacrylamide) (PNIPAM) and dialdehyde
dextrin. The mechanical strength and stability of the hydrogel were
reinforced by the introduction of intermolecular hydrogen-bonding
from poly(N-acryloyl glycinamide) (PNAGA), which
possesses great biocompatibility and similarity to PNIPAM. The internal
morphology, dynamic moduli, de-cross-linking properties, and temperature
responsiveness of the hydrogels were systematically investigated.
Upon hydrogen-bonding reinforcement, the hydrogel elasticity, reflected
by the maximum storage modulus, dramatically increased from 90.2 to
517.0 kPa, which is about a 570% increase compared with unreinforced
hydrogels. In addition, the mechanical properties of the hydrogel
were reinforced as the de-cross-linking could be inhibited by PNAGA-based
hydrogen-bonding. The temperature release behavior of the hydrogel
was assessed with a model drug (propranolol hydrochloride, PHCl) and
could be precisely controlled by adjusting the environmental temperature
between 25 and 37 °C. Therefore, PNAGA reinforced thermoresponsive
hydrogels are promising functional biological materials for use in
tissue-repair engineering and controlled-release drug delivery.
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