Chronic Injury Of Human Renal Microvessels With Low-dose Cyclosporine Therapy

Physiologic and morphologic techniques were used to study kidneys of cardiac transplant recipients treated with either low-dose (low-CsA) or high-dose (high-CsA) cyclosporine. After 12 months both low-CsA (4.6±0.4) and high-CsA (6.3±0.3 mg/Kg/24 hr, p 2-fold (P