Synthesis of ring-substituted N-benzyl γ-phenyl GABA derivatives via reductive amination

Background: GABA derivatives are important for the development of drugs for disorders of the CNS and PNS. Results: We describe a simple synthesis of N-benzyl γ-phenyl-γ-aminobutyric acids, via the reductive amination of the corresponding γ-keto acids with benzylamines using ammonia borane. Conclusion: This procedure provides an efficient and economical method for the synthesis of GABA derivatives.