Squamous cell carcinoma of the prostate with concomitant adenocarcinoma in the absence of prior androgen deprivation therapy

We present a case of squamous cell carcinoma of the prostate, unique in that it was accompanied by a spatially separate focus of high-grade adenocarcinoma. Unlike previous case reports, the patient had no history of prior prostatic adenocarcinoma and had no history of treatment with antiandrogen or radiation therapy. Prostate carcinomas with squamous differentiation, while exceedingly rare, carry a poor prognosis compared to adenocarcinomas and should be considered in male patients with obstructive urinary symptoms without increased serum prostate specific antigen.