Abstract 19060: Relationship of Myocardial Strain by 2D Speckle Tracking Echocardiography and Coronary Flow Reserve by Magnetic Resonance Imaging in Patients with Heart Failure with Preserved Ejection Fraction

Introduction: A recent study demonstrated that myocardial strain assessed by 2D speckle tracking echocardiography (2D-STE) is significantly reduced in heart failure with preserved ejection fraction (HFpEF). Phase contrast (PC) cine magnetic resonance (MR) imaging allows for non-invasive and accurate evaluation of microcirculation of myocardium, namely coronary flow reserve (CFR). Hypothesis: We hypothesized that both myocardial strain by 2D STE and CFR by PC cine MRI are substantially reduced in patients with HFpEF in comparison those without and myocardial strain by 2D-STE is correlated with CFR by PC cine MRI. Methods: We studied 20 HFpEF patients (mean age: 72 ± 6 years) and 18 controls (mean age: 66 ± 13 years). Assessment of myocardial strain was performed in three directions, radial strain (RS); circumferential strain (CS); longitudinal strain (LS). By using 1.5T MR scanner and 32 channel cardiac coils, breath-hold PC cine MR images of coronary sinus (CS) were obtained to assess the blood flow of CS...