Synthesis, radiosynthesis and positron emission tomography neuroimaging using 5‐[18F]fluoro‐L‐amino suberate

System xc detect oxidative and excitotoxic stress. Notably, applications have, thus far, been limited to tumour imaging although Sxc (-) ) may play a major role in neurodegeneration. The synthesis procedures of tosylate precursor and its translation to Sxc - PET tracer 5[18F]fluoro-L-amino suberate by manual and automated radiosyntheses are described. A brain-PET study has been conducted to evaluate the tracer uptake into brain in healthy mice.