Recycling method of rabeprazole thioether

2015 
The invention relates to a recycling method of rabeprazole thioether. The recycling method comprises the following steps: washing a to-be-recycled dichloromethane solution containing rabeprazole thioether with a methanol solution and water in sequence; distilling under normal pressure and recycling dichloromethane; dissolving distillation residues with an alkaline solution, regulating a pH value of the system with an acid solution to separate out rabeprazole thioether, and filtering to obtain a solid, pulping the solid with water, and recycling to obtain rabeprazole thioether which is consistent with rabeprazole thioether on the market in quality. The recycling method has the beneficial effects that the recovery rate of the rabeprazole thioether is 55-65%, and the distilled and recycled dichloromethane can be utilized in a process of preparing rabeprazole from the abeprazole thioether. The recycling method is applied, so that the raw material cost of the rabeprazole sodium is reduced by about 8%, and the environmental pollution can be reduced.
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