Comparison of Visual and Quantitative 18F-Florbetaben PET Scan Assessment

1567 Objectives Visual assessment of 18F-Florbetaben (FBB) PET scans is recommended in clinical practice. Quantification using SUVRs is often used for research purposes. The added value of quantification for the clinical scan report is still unknown. This study aims to compare both assessment methods of FBB PET scans. Methods A total of 109 scans from n=70 young (27.7 ± 5.1 yrs) cognitively normal subjects (HVs) assumed to be devoid of brain beta-amyloid and n=39 subjects with Down syndrome (DS) > 40 yrs old (46.3 ± 4.7 yrs), were visually assessed by 3 readers using the brain amyloid plaque load (BAPL) scoring system, where negative scan=BAPL 1, and positive scan is either BAPL 2=moderate or BAPL 3= pronounced tracer uptake. Positive or negative scan agreement in ≥2 readers was considered as the scan result. A composite SUVR using cerebellar cortex as reference was obtained from the average SUVR in 6 cortical regions, using an automated grey/white matter MRI segmentation and PET-MRI co-registration. Composite SUVR ≥1.45 were considered positive. Results All scans from HVs were visually assessed as negative. 92.7% of the scans were equally classified as positive or negative by both visual and quantitative approaches (table). Both methods were significantly and strongly related (X2 = 50.1837, p Conclusions These findings support the use of either visual or quantitative assessment of FBB scans. Further investigation is required to determine the utility of SUVR quantification in challenging scans. Research Support Piramal Imaging