Antitumor effect of heat-killed lactobacilli adhered to cervical carcinoma cells

AIM:To observe the immune property of cervical carcinoma and antitumour effect of heat-killed lactobacilli adhered to HeLa cells.METHODS:Flow cytometry was used to analyze the expression of immune molecules on HeLa cells after adhered with heat-killed lactobacilli.MTT was used to analyze the cytotoxity of lymphocytes on cervical carcinoma cells.RESULTS:Adherence of heat-killed lactobacilli to HeLa cells did not affect the expression of MHC-I molecules(P0.05),but enhanced the expression of CD80,CD86 significantly(P0.05)in HeLa cells.Adherence of heat-killed lactobacilli to HeLa cells also enhanced the cytotoxity of NK cells.Compared to control,the cytotoxity of CTL to HeLa carcinoma cells was significantly enhanced by the adherence of heat-killed lactobacilli to HeLa cells(P0.05).CONCLUSION:Heat-killed lactobacilli strengthen the antitumor effect on HeLa cells.