A comparative analysis of in vivo toxicity, larvicidal and catalytic activity of synthesized silver nanoparticles

In this study, mosquito larvicidal, photocatalytic activities and in vivo biocompatibility in Wistar rats studies of synthesized silver nanoparticles (AgNPs) from Acacia nilotica (An) and its purified compound pyrogallol (Py) were examined. In in vivo studies, rats in various groups were administrated intraperitoneal injection with 20 and 40 mg/kg body weight (BW) of An-AgNPs and Py-AgNPs for 14 days for once in a day. Histology analysis of major organs, such as liver, kidney, spleen, lung, and heart, indicates normal structure at particular doses of An-AgNPs and Py-AgNPs; however, 40 mg/kg BW of An-AgNPs showed lower toxicity level. An-AgNPs and Py-AgNPs showed good larvicidal activity against Culex quinquefasciatus (C. quinquefasciatus) and Aedes aegypti (A. aegypti) and showed good photo-catalytic activity against methylene blue (MB) dye. However, An-AgNPs showed higher (82.93%) catalytic activity in 150 min. Thus, the present study will support the use of synthesized Py-AgNPs in the future in vivo applications, and An-AgNPs may act as a water pollution-controlling agent.