A worldwide analysis of AG molecular diversity inferred from serology.
2001
Ten population samples from different geographic
origins were tested serologically for the AG polymorphism of human
b-lipoproteins. Their haplotype frequencies were used with
previously published data to perform a wide analysis of AG genetic
differentiations throughout the world. Coancestry coefficients were
computed from weighted FSTs among populations by
using a matrix of molecular distances among AG haplotypes, which is here
determined on the basis of DNA studies. Coancestry coefficients derived
from unweighted FSTs and more classical Prevosti
distances were computed on the same data and used for a comparison. In
all cases a highly significant correlation was found between genetics
and geography on a worldwide scale, while the significance of the
correlation with linguistics differed. A test of significance of the
pairwise FSTs among populations also gave different
results depending on whether the molecular distance matrix among AG
haplotypes was included. Globally, this study shows that in spite of
being highly significantly correlated to each other, different genetic
distance measures can lead to different interpretations of the same data
set. Moreover, the elucidation of the molecular models related to the
presently known serological polymorphisms may represent an additional tool
for analyzing such polymorphisms in human population genetics studies.
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