TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch

Previous work has shown that two members of the Mas-related GPCR family, MrgprA3 and MrgprC11, mediate histamine-independent itch signaling. Here, Wilson et al. demonstrate that TRPA1 is a downstream target of both of these receptors in sensory neurons and is required for Mrgpr-evoked itch.