Biobanking for COVID-19 research

BACKGROUND: Biobanks are imperative infrastructures, particularly during outbreaks, when there is an obligation to acquire and share knowledge as quick as possible to allow for implementation of science-based preventive, diagnostic, prognostic and therapeutic strategies METHODS: We established a COVID-19 biobank with the aim of collecting high-quality and well-annotated human biospecimens, in the effort to understand the pathogenic mechanisms underlying COVID-19 and identify therapeutic targets (COVID-BioB, NCT04318366) Here we describe our experience and briefly review the characteristics of the biobanks for COVID-19 that have been so far established RESULTS: A total of 46,677 samples have been collected from 913 participants (63 3% males, median [IQR] age 62 2 [51 2 - 74 0] years) since the beginning of the program Most patients (66 9%) had been admitted to hospital for COVID-19, with a median length of stay of 15 0 (9 0 - 27 0) days A minority of patients (13 3% of the total) had been admitted for other reasons and subsequently tested positive for SARS-CoV-2 The remainder were managed at home after being seen at the Emergency Department CONCLUSIONS: Having a solid research infrastructure already in place, along with flexibility and adaptability to new requirements, allowed for the quick building of a COVID-19 biobank that will help expand and share the knowledge of SARS-CoV-2