Synthesis and central nervous system stimulant activity of 5,8-methanoquinazolines fused with 1,2,4-triazole, tetrazoleand 1,2,4-triazine

5,8-Methanoquinazolines fused with 1,2,4-triazole 4–5, tetrazole 6, and 1,2,4-triazine 8 were prepared starting from 2-hydrazino-5,8-methanoquinazoline 3. Compound 3 and 6 showed the most potent central nervous system (CNS) stimulant activities.