Apparent late-onset cockayne syndrome and interstitial deletion of the long arm of chromosome 10 (del(10)(q11.23q21.2))

We present the history and data on a 24-year-old man with clinical and neurological symptoms similar to the findings in patients with late-onset Cockayne syndrome. Prometaphase chromosome studies documented an interstitial 10q211 deletion in all cells. This finding may indicate that the gene for late Cockayne syndrome is at 10q211.