2P-168 : Photodynamic Therapy for treat acnes using nanoparticles which loaded polymer conjugated photosensitizer to enhance of skin penetration

In recent years, Photo Dynamic Therapy (PDT) has been proposed their potentials to treat acne using Photosensitizer(PS) or PS-conjugated drugs. However, drug resistance and side-effects are acting as barriers in their bio-application. In this study, we solve these problems to fabricate nanoparticles which loaded polymer-conjugated PS for enhencing skin cell penetration. After irradiation of specific wave lengh, there are remarkable results in PS loaded nanoparticle group. Using Franz cell diffusion system, we compare the tissue penetration efficiency between free PS and PS loaded nanoparticles. As a result, PS loaded nanoparticles group has higher skin permeability than free PS group. In addition, PS loaded nanoparticles group exhibited the 2-fold, 1.5-fold higher toxicity of acnes than conventional antibiotics group and PS conjugated with cationic polymers group. Consequently, PDT with PS loaded nanoparticles is effective for the treatment of acnes.