Logistic regression analysis of high risk factors of post-thrombotic syndrome after lower extremity deep venous thrombosis

Objective To explore the high risk factors of post-thrombotic syndrome (PTS) after lower extremity deep venous thrombosis(DVT). Methods During January 2014 to September 2017, from department of vascular surgery of Qingpu branch of affiliated Zhongshan Hospital of Fudan University, 159 patients with lower limb DVT were retrospectively analyzed. Finally, 109 patients met inclusion criteria were included. All patients received normative anti-coagulation and thrombolytic therapy according to the guideline. The incidence of PTS was evaluated according to the Villalta scale during the 1-year follow-up. The patients were divided into two groups including experimental group (PTS, 29) and control group (No PTS, 80) based on whether having PTS. And the patients` data including personal information, past and present history, body mass index and location of thrombus were recorded. The rate and high risk factors of PTS were evaluated by Logistic regress analysis. Results The incidence rate of PTS was 26.6% (29/109) within a year, 4.6% (5/109) was severe PTS. Obesity (OR=3.71, 95%CI 1.24~11.13), disease progress longer than 2-weeks (OR=5.56, 95%CI 1.84~16.83), varicose vein of lower limb (OR=5.36, 95%CI 1.69~17.00), iliofemoral deep venous thrombosis (OR=3.58, 95%CI 1.21~10.58) and cancer (OR=3.53, 95%CI 1.04~11.98) were the major risk factor of PTS. Conclusions Obesity, longer disease progress, iliofemoral venous thrombosis, varicose vein and cancer were the high risk factors of PTS after DVT. Key words: Post-thrombotic syndrome; High risk factors; Logistic analysis