[Prospective study of gluco-lipidic hormone and peptide levels in morbidly obese patients after sleeve gastrectomy].

Abstract Introduction Different hormones and peptides involved in lipid and carbohydrate metabolism have been studied in relation to morbid obesity and its variation after bariatric surgery. The aim of this study is to evaluate variations in different molecules related to gluco-lipidic metabolism during the first year after sleeve gastrectomy in morbidly obese patients. Materials and methods This is a prospective study in patients undergoing sleeve gastrectomy between November 2009 and January 2011. We analysed changes in different clinical, anthropometric and analytic parameters related with gluco-lipidic metabolism in all patients in the preoperative period, first postoperative day, fifth day, one month, 6 months and one year after surgery. Statistical analysis was performed using SPSS 20.0. Results We included 20 patients, 60% were women with a median age of 45 years and the median of body mass index (IMC) was 48.5 kg/m 2 , 70% had obstructive sleep apnea syndrome (SAOS), 65% arterial hypertension (HTA), 45% dyslipidemia and 40% diabetes mellitus. One year after surgery, the percentage of excess of BMI loss was 72% and the rate of cure or improvement of dyslipidemia was 100%, diabetes 87.5%, HTA 84.6% and SAOS 57.1%. At this time, glycemia levels decreased significantly ( P .001), and levels of IGF-1 and HDL-cholesterol increased significantly. Levels of adiponectine increased and those of leptine ( P =.003), insulin ( P =.004) and triglycerides ( P =.016) decreased significantly one year after the surgery. ACTH levels (that decreased during first 6 months after surgery), glycosylated haemoglobin, total cholesterol and LDL-cholesterol had no changes one year after surgery. Conclusions Sleeve gastrectomy is a surgical technique with good results of weight loss and cure of comorbidities. This procedure induces significant modifications in blood levels of gluco-lipidic metabolism related peptides and hormones, such as glucose, IGF-1, insulin, leptin, triglycerides and HDL-cholesterol.