SERS detection of low-concentration adenosine by silver nanoparticles on silicon nanoporous pyramid arrays structure

Abstract A novel surface-enhanced Raman spectroscopy (SERS) substrate based on uniform silver nanoparticles/silicon nanoporous pyramid arrays (Ag/PS) is prepared and SERS behaviors to adenosine are discussed and compared. With a low concentration of 10 −7  M, the characteristic Raman bands of adenosine demonstrate the significantly high SERS sensitivity of the prepared Ag/PS substrate. A reasonable linear correlation is obtained between the intensity of SERS signal and the adenosine concentration from 10 −2 to 10 −7 M in log scale. These results imply that the Ag/PS with regular pyramids array might be an effective substrate for performing label-free sensitive SERS detections of biomolecule.