THREE PHENOLIC GLYCOSIDES AND IMMUNOLOGICAL PROPERTIES OF ACHILLEA MILLEFOLIUM FROM IRAN, POPULATION OF GOLESTAN

From MeOH extract of aerial parts of Achillea millefolium L. collected from Golestan province of Iran, three glycosylated phenolic compounds, luteolin 7-O-glucoside, apigenin 7-O-glucoside and caffeic acid glucoside were isolated and identified by spectroscopic analyses. Immunological properties of different fractions of plant extract were studied on humoral immune system of BALB/c mice by Microhaemagglutination test. Among these fractions only two fractions at 125 mg kg -1 and 61.5 mg kg -1 showed a significant decrease in the anti- SRBC titer of mice (P<0.05). The immunological properties of the latter fractions may be due to glycosylated derivatives of caffeic acid.