Stereospecific and Kinetic Control over the Hydrolysis of a Sterically Hindered Platinum Picoline Anticancer Complex

The new anticancer complexcis-[PtCl2(15NH3)(2-picoline)] (1) and its 3-picoline analogue differ from cisplatin in reactivity. The hydrolysis rates for each chloride ligand of the two complexes and the pKa values of their aqua and diaqua adducts have been determined by [1H, 15N] 2 D NMR spectroscopy. These data, together with X-ray crystal structures, provide an explanation for the difference.