G-Protein Peptidomimetics Stabilize GPCR Active State Conformations
2021
Technologies stabilizing the active state of G protein-coupled receptors (GPCRs) represent potential breakthroughs for interrogating G protein activation. Camelid nanobodies have been used as a 'one tool, one receptor' paradigm. However, the development of G protein peptidomimetics, as discussed in Mannes et al. represent the opportunity to develop generically activating probes for many GPCRs.
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