Methylene blue increases systemic vascular resistance in human septic shock : preliminary observations
1992
We report the hemodynamic improvements induced by intravenous methylene blue (MB), a guanylate cyclase inhibitor, in 2 patients with hyperdynamic septic shock treated with norepinephrine (NE) infusion, mechanical ventilation and hemodialysis. MB injection augmented the low vascular resistance, mean arterial pressure and induced a slight decrease of cardiac index, without any change of heart rate and pulmonary artery wedge pressure. Plasma cyclic GMP levels decreased without a significant change of atrial natriuretic factor levels
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
10
References
114
Citations
NaN
KQI