Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate

Sawako Muroi,Yoshinori Naoe,Chizuko Miyamoto,Kaori Akiyama,Tomokatsu Ikawa,Kyoko Masuda,Hiroshi Kawamoto,Ichiro Taniuchi

Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate

2008

Sawako Muroi
Yoshinori Naoe
Chizuko Miyamoto
Kaori Akiyama
Tomokatsu Ikawa
Kyoko Masuda
Hiroshi Kawamoto
Ichiro Taniuchi

The transcription factor ThPOK is required for CD4+ T cell differentiation. Groups led by Taniuchi, Bosselut and Littman define distinct functions for ThPOK and other transcription factors in commitment versus specification of the CD4+ T cell lineage.

Keywords:

Immunology
Cell biology
DNA-binding protein
Transcription factor
Molecular mechanics
Cytotoxic T cell
Cellular differentiation
Major histocompatibility complex
Biology
T cell
Molecular biology
t cell differentiation

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