P113 Reduced exosomes expression in BAL fluid from fibrotic interstitial lung disease due to blockage of autophagy in alveolar macrophages

Background: Blockage of autophagic pathways had been reported in IPF. Exosomes are microvesicles that mediate a variety of biological functions. Compromised autophagy can modify cellular exosomes release. Aims: We aimed to study alveolar macrophage (AMo) autophagy and exosomes in the BALf of patients with fibrotic interstitial lung disease (ILD). We hypothesized that impaired autophagy …