Local Graft Irradiation for Kidney Allograft Rejection: A Case Series and Review of the Literature

Summary of Studies Reporting the Use of LGI as a Second Line of Therapy for Acute Kidney Allograft Rejection a, b Author Number of PatientsSelection Criteria Dose Range, cGyMedian Dose, cGyOne Month Graft Survival Post-LGI, %One Year Graft Survival Post-LGI, %Halperin et al. (12) 53 Refractory acute allograft rejec-tion 300-1200 600 42 2110 Acute allograft rejection with con-traindicated immunosuppressive therapy due to systemic infection or hematologic dyscrasias300-1200 600 90 40 Jagetia et al. (13) 6 Refractory acute allograft rejec-tion 450-600 450 50 17 Noyes et al. (14) 72 Refractory acute allograft rejec-tion 800 800 NA 49 Chen et al. (17) 53 Refractory acute allograft rejec-tion (75 % of patients)600 600 83 60 Nuyttens et al. (15) 20 Refractory acute allograft rejec-tion 450 450 NA 50 Wahl et al. (16) 33 Refractory acute allograft rejec-tion 800 800 63 31 Current study 6 Refractory acute allograft rejec-tion 800–600 733 83 17 a Abbreviations: LGI, local graft irradiation; NA, not available.b Biopsy proven acute allograft kidney rejection resistant to medical therapy.