A retrospective study of hyperurecemia in renal transplant recipients

Objective: This study was designed to estimate the prevalence, risk factors of post transplant hyperuricemia and to establish the serial changes in eGFR and uric acid in adult renal transplant recipients. Methods: A retrospective observational study on 84 adult renal transplant recipients was conducted between January 2012 and January 2014 in PGIMER and Dr RML hospital, New Delhi, India. Clinical and laboratory data were obtained from hospital electronic database. Results: Of 84 patients selected for this study 56 were males and 28 females. The median age was 31 yrs. Hyperuricemia was detected in 48.9% of the recipients at one month from transplantation. After 6 months there is a 15% increase in the number of hyperuricemic subjects. Mean eGFR decreased significantly along with an increase in the uric acid concentration during first year in the patients found hyperuricemic at 1 month of transplantation. Conclusion: eGFR, serum phosphorus, serum cholesterol levels were risk factors for hyperuricemia in renal recipients. The risk is more in subjects who demonstrated increase uric acid level immediately post transplant.