Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase

Abstract An array of novel analogues of the marine oxylipins, the manzamenones and plakoridines, have been prepared in divergent fashion using an approach modelled on a biogenetic theory. Many of the target compounds show potent inhibition of DNA polymerases α and β and human terminal deoxynucleotidyl transferase (TdT).