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Synthetic method for chlorfenapyr

2014 
A synthetic method for chlorfenapyr mainly comprises the following steps: (2) synthesizing an intermediate 4-(p-chlorophenyl)-2-trifluoromethyl-3-oxazoline-5-one; (2) synthesizing an intermediate 2-(p-chlorophenyl)-5-trifluoromethyl-pyrrole-3-carbonitrile; (3) synthesizing an intermediate 4-bromo-2-(p-chlorophenyl)-5-trifluoromethyl-pyrrole-3-carbonitrile; and (4) synthesizing the target product chlorfenapyr, that is 4-boromo-2-(p-chlorophenyl)-1-ethoxymethyl-5-trifluoromethyl-pyrrole-3-carbonitrile. All raw materials for synthesis of the raw pesticide are abundant in resource, the synthetic technology is mild in reaction conditions and suitable for industrialized production.
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