Polyomavirus BK and its role in associated kidney transplantation pathology

: In the last three decades kidney transplantation became a therapeutic approach in Romania but, unfortunately, the increasing of kidney transplantation procedures is related to an increasing rate of associated pathology such as Polyomavirus BK Associated Nephropathy (BKVAN). Studies published recently emphasize that BKVAN is a consequence of different risks factors, particular viral pathogenesis, humoral and cellular immunity and high doses of immunosuppressive drugs used for a long time are the main conditions that influence the BKVAN's evolution. Since there is no specific and effective treatment, optimal medical management is to diagnose nephropathy in early stages, to stop viral replication, limiting tubular lesions and prevent progress toward destruction by decreasing doses of immunosuppressive agents.