Abstract 246: Reduced Prehospital Survival Rate After Out-of-Hospital Cardiac Arrest in Patients with Diabetes Mellitus Type 2: A Prospective Community-Based Study

Objectives: Out-of-hospital cardiac arrest (OHCA) remains a major cause of death. We aimed to determine whether diabetes mellitus type 2 (T2DM) is associated with survival to hospital admission and to hospital discharge after OHCA. Methods: We performed a community-based cohort study of 1549 OHCA patients with ECG-documented ventricular tachycardia/ventricular fibrillation (VT/VF). Survival to hospital admission and to hospital discharge was compared between patients with T2DM and non-DM patients using multivariate logistic regression analysis. Among discharged patients, we compared the proportions of neurologically intact (NI) survival. All analyses were stratified according to T2DM disease severity. Results: Patients with T2DM (n=275) had lower survival rates to hospital admission than non-DM patients (n=1274, 48.7% vs. 55.8%, P=0.032). Patients with severe T2DM had lower survival rates to admission than patients with mild T2DM (37.3% vs. 53.3%, P=0.034). Multivariate analysis revealed that T2DM was an independent determinant of survival to hospital admission (OR 0.75 [95% CI 0.58-0.98]). Survival rates to hospital discharge were also lower in patients with T2DM (n=134) than in non-DM patients (n=711, 40.3% vs. 57.7%, P Conclusion: Patients with T2DM had lower survival rates to hospital admission and to hospital discharge after OHCA than non-DM patients. T2DM was an independent determinant of lower survival.