Is Polymerase Chain Reaction in Neonatal Dried Blood Spots Reliable for the Diagnosis of Congenital Cytomegalovirus Infection

Isabel Vives-Oñós,María Gema Codina-Grau,Antoni Noguera-Julian,Daniel Blázquez-Gamero,Claudia Fortuny,Fernando Baquero-Artigao,Marie Antoinette Frick,Jesús Saavedra-Lozano,Walter Goycochea-Valdivia,María Teresa Rives-Ferreiro,Abián Montesdeoca Melián,Olga Calavia Garsaball,Laura Ferreras Antolin,José Luis Marín Soria,Elena Dulin Iñiguez,Pere Soler Palacín

Is Polymerase Chain Reaction in Neonatal Dried Blood Spots Reliable for the Diagnosis of Congenital Cytomegalovirus Infection

2019

Isabel Vives-Oñós
María Gema Codina-Grau
Antoni Noguera-Julian
Daniel Blázquez-Gamero
Claudia Fortuny
Fernando Baquero-Artigao
Marie Antoinette Frick
Jesús Saavedra-Lozano
Walter Goycochea-Valdivia
María Teresa Rives-Ferreiro
Abián Montesdeoca Melián
Olga Calavia Garsaball
Laura Ferreras Antolin
José Luis Marín Soria
Elena Dulin Iñiguez
Pere Soler Palacín

Background:Detection of cytomegalovirus (CMV) DNA by real-time polymerase chain reaction (rt-PCR) in dried blood spots (DBSs) collected for newborn screening has been assessed for retrospective diagnosis of congenital CMV (cCMV) infection, with variable results (sensitivities ranging from 34% to 100

Keywords:

Virology
Polymerase chain reaction
Medicine
cytomegalovirus infection
Spots
Newborn screening
Retrospective diagnosis
dried blood
Congenital cmv

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