Inhibitory effect of PACAP(6–38) on relaxations induced by PACAP, VIP and non-adrenergic, non-cholinergic nerve stimulation in the guinea-pig taenia caeci

The effect of the pituitary adenylate cyclase activating polypeptide (PACAP) receptor antagonist PACAP(6–38) on the relaxant response to exogenous PACAP, vasoactive intestinal polypeptide (VIP) and non-adrenergic, non-cholinergic (NANC) nerve stimulation was tested in the guinea-pig taenia caeci, in the presence of atropine (10–6 M) and guanethidine (3×10–6 M).