Synthesis of Chiral (Sulfinyl)furyloxazoline Ligands and Its Application to Enantioselective Palladium-Catalyzed Allylic Alkylation

2008 
Chiral ligands containing an oxazoline substituent and a sulfur functionality at the furan ring have been synthesized and examined for enantioselective palladium catalyzed allylic substitution reaction. The enantioselectivity observed was found to be dependent upon the nature of the sulfur center and oxazoline group, up to 91% ee was given with chiral (3-sulfinyl)furan-2-yl ligand.
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