Synthesis of Optically Active Selenium-Containing Isotryptophan, Homoiso­tryptophan, and Homotryptophan

Selenoisotryptophan and its higher homologues were synthesized by Sonogashira coupling of iodophenyl methyl selenide and alkynyloxazolidines followed by iodocyclization as the key step. Sonogashira coupling of 3-iodobenzoselenophene with ethynyloxazolidine allowed the synthesis of selenohomotryptophan.