Assessment of correlation between Brain Natriuretic Protein test and early prognosis in Acute Coronary Syndrome

Abstract The aim of this study was to determine; the relationship between Brain Natriuretic Protein (BNP) and early prognosis in Acute Coronary Syndrome (ACS). In this analytical study, 158 patients with ACS admitting to Emergency Department of Rasul Akram hospital in Tehran entered in study. For each patient, information include of demographic, past medical history, drug therapy, presenting symptoms and signs, results of serum chemistry test, radiographic studies, electrocardiography and NT-proBNT test that measured using immunoassay were collected. Totally 158 patients with mean age of 59.7 +/- 0.95 that 86(54.4%) of them were male included in study. The ROC curve showed that BNP more than 612 (pg/ml) had sensitivity and specificity of 98% in predicting the outcome (discharged vs. CCU admission) which had a Positive predictive value (PPV) of 99% and Negative predictive value (NPV) of 96%, while in another ROC curve analysis BNP greater than 3200(pg/ml) had a sensitivity of 81%, specificity of 92% in predicting heart failure, fatal arrhythmia or death as an outcome with a PPV of 37.5% and NPV of 98.5%. Results demonstrate NT-proBNP for strongly predicted short-term outcomes in subjects with chest pain, with 1.2 increases in risk for death by 7 days among those with marked elevation in NT-proBNP concentration. Other studies have found similar results.