Enhancing cGMP in experimental progressive renal fibrosis: soluble guanylate cyclase stimulation vs. phosphodiesterase inhibition

Yingrui Wang,Stephanie Krämer,Tanja Loof,Sebastian Martini,Susanne Kron,Hiroshi Kawachi,Fuijo Shimizu,Hans-H. Neumayer,Harm Peters

Enhancing cGMP in experimental progressive renal fibrosis: soluble guanylate cyclase stimulation vs. phosphodiesterase inhibition

2006

Yingrui Wang
Stephanie Krämer
Tanja Loof
Sebastian Martini
Susanne Kron
Hiroshi Kawachi
Fuijo Shimizu
Hans-H. Neumayer
Harm Peters

cGMP serves as the main second messenger of nitric oxide (NO). Antifibrotic effects of enhancing renal cGMP levels have recently been documented in experimental acute anti-Thy-1 glomerulonephritis....

Keywords:

Diabetes mellitus
Pentoxifylline
Fibrosis
Biochemistry
Second messenger system
Nitric oxide
Stimulation
Endocrinology
Internal medicine
Glomerulonephritis
Medicine
Phosphodiesterase
Guanylate cyclase
renal fibrosis

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